Therapiefaktor Myokine – Des Muskels Botenstoff

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منابع مشابه

Hasselbach W & Makinose M. Die Calciumpumpe der “Erschlaffungsgrana” des Muskels und ihre Abhangigkeit von der ATP-Spaltung. Biochemische Zeitschrift 333:518-28, 1961

“In the late-1950s, after in vitro experiments performed with isolated contractile proteins had furnished conclusive evidencei that AIR was the sole energy source of the contractile apparatus, the problem emerged as to how the ATP hydrolysing activity of the contractile proteins in the living muscle was switched on and off during a contraction relaxation cycle. The road was opened by the discov...

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Irisin – a myth rather than an exercise-inducible myokine

The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5), and to mediate beneficial effects of exercise on human metabolism. However, evidence for irisin circulating in blood is largely based on commercial ELISA kits which are based on polyclonal antibodies (pAbs) not previously tested for cross-reacting serum proteins. We hav...

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Musclin is an activity-stimulated myokine that enhances physical endurance.

Exercise remains the most effective way to promote physical and metabolic wellbeing, but molecular mechanisms underlying exercise tolerance and its plasticity are only partially understood. In this study we identify musclin-a peptide with high homology to natriuretic peptides (NP)-as an exercise-responsive myokine that acts to enhance exercise capacity in mice. We use human primary myoblast cul...

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LIF is a contraction-induced myokine stimulating human myocyte proliferation.

The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine functioning in an autocrine fashion to activate gene regulation of human muscle satellite cell proliferation. Skeletal muscle LIF expression, regulation, and action were examined in two models: 1) young men performing a b...

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Irisin, a novel myokine: potential role in obesity and diabetes

Obesity is a worldwide health problem that results in a signifi cant increased risk of morbidity and mortality. While we know that obesity is the consequence of a chronic imbalance between energy intake and energy expenditure, how energy expenditure is regulated in humans is not clearly understood. Recent publications suggest that specifi c depots of white adipose tissue can be converted to the...

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ژورنال

عنوان ژورنال: physiopraxis

سال: 2017

ISSN: 1439-023X,1869-5515

DOI: 10.1055/s-0043-101662